SMAD 3 expression and regulation of fibroplasia in vocal fold injury
نویسندگان
چکیده
منابع مشابه
Regulation of vocal fold transepithelial water fluxes.
Vocal fold hydration is critical to phonation. We hypothesized that the vocal fold generates bidirectional water fluxes, which are regulated by activity of the Na(+)-K(+)- ATPase. Western blots and immunohistochemistry demonstrated the presence of the alpha-subunit Na(+)-K(+)-ATPase in the canine vocal fold (n = 11). Luminal cells, basal and adjacent one to two layers of suprabasal cells within...
متن کاملClassification for animal vocal fold surgery: resection margins impact histological outcomes of vocal fold injury.
OBJECTIVES/HYPOTHESIS Extent of vocal fold injury impacts the nature and timing of wound healing and voice outcomes. However, depth and extent of the lesion created to study wound healing in animal models vary across studies, likely contributing to different outcomes. Our goal was to create a surgery classification system to enable comparison of postoperative outcomes across animal vocal fold w...
متن کاملCharacterization of the Leukocyte Response in Acute Vocal Fold Injury
Macrophages location in the superficial layer of the vocal fold (VF) is not only at the first line of defense, but in a place of physiologic importance to voice quality. This study characterizes and compares macrophage function in two models of acute injury. Porcine VF injuries were created bilaterally by either surgical biopsy or lipopolysaccharide (LPS) (1.5 μg/kg) injection. Animals were sac...
متن کاملRegulation of Wound Healing by Granulocyte-Macrophage Colony-Stimulating Factor after Vocal Fold Injury
OBJECTIVES Vocal fold (VF) scarring remains a therapeutic challenge. Granulocyte-macrophage colony-stimulating factor (GM-CSF) facilitates epithelial wound healing, and recently, growth factor therapy has been applied to promote tissue repair. This study was undertaken to investigate the effect of GM-CSF on VF wound healing in vivo and in vitro. METHODS VF scarring was induced in New Zealand ...
متن کاملStructural and functional vocal fold epithelial integrity following injury.
OBJECTIVES/HYPOTHESIS An intact epithelium is an important part of vocal fold defense. Damage to the epithelium can compromise vocal fold homeostasis and protection of the host tissue from viral and bacterial invasion. Elucidating the effects of damage on epithelial architectural and barrier integrity provides insight into the role of epithelium in protecting vocal folds. Using an animal model,...
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ژورنال
عنوان ژورنال: The Laryngoscope
سال: 2017
ISSN: 0023-852X
DOI: 10.1002/lary.26648